One of the most difficult challenges organizational leaders face is change resistance. Even changes that seem minor can breed discontent and disengagement, while large changes can lead to productivity slowdowns and employee turnover. Given the accelerating pace of change in organizations, leaders can no longer afford to ignore the issue or blame it on “bad attitudes.” The fact is, everyone—leaders and line employees alike—has a brain that is hard-wired to resist change. To overcome resistance and manage change better, we need to understand how the brain works. This article is an overview of an APQC webinar, where Ghita Benkirane, managing director of Art & Management, explained how leaders can use neuroscience insights to understand and manage change resistance.