Knowledge management strategies in any organization are exceptionally complex. In pharmaceutical R&D, KM can be a monster. Consider unique business needs, the cross-functional nature of R&D, and a multi-discipline, multi-generational workforce with up to half ready to retire in five years. All factors align to create an urgent need for a multi-faceted, integrated, hands-on approach to capturing, managing, sharing, and leveraging valuable knowledge. This presentation describes the KM strategy, approach, successes, and lessons learned at AbbVie.